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Anti Estrogen Steroids Nolvadex / Tamoxifen Citrate For Steroid Cycle Post Cycle Therapy ( PCT) 54965-24-1

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Anti Estrogen Steroids Nolvadex / Tamoxifen Citrate For Steroid Cycle Post Cycle Therapy ( PCT) 54965-24-1

China Anti Estrogen Steroids Nolvadex / Tamoxifen Citrate For Steroid Cycle Post Cycle Therapy ( PCT) 54965-24-1 supplier

Large Image :  Anti Estrogen Steroids Nolvadex / Tamoxifen Citrate For Steroid Cycle Post Cycle Therapy ( PCT) 54965-24-1

Product Details:

Place of Origin: China
Brand Name: Hongkong SaiChuang
Certification: ISO9001
Model Number: Anti Estrogen Steroid

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Minimum Order Quantity: 10g
Price: negotiable USD
Packaging Details: safe discreet package
Delivery Time: within 12 hours after payment
Payment Terms: Western Union, L/C, , D/A, MoneyGram, T/T, D/P
Supply Ability: 1000KG/month
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Detailed Product Description
Name: Nolvadex / Tamoxifen Citrate Cas: 54965-24-1
MF: C28H36O3 MW: 420.58
Purity: 99% Storage: 2-8°C
Appearance: White Crystalline Powder Packaging: Discreet Packaging
Origin: China Whatsapp: +8618873306038
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Anti Estrogen Steroids Nolvadex / Tamoxifen Citrate For Steroid Cycle Post Cycle Therapy ( PCT) 54965-24-1
Tamoxifen citrate
Product name: Tamoxifen citrate
Synonyms: kessar; noltam; tamofen; Tamoxifen citrate
: 54965-24-1
EINECS: 259-415-2
Assay: 99%-101%. USP31
MF: C32H37NO8
MW: 563.64
Usage :pharmaceutical raw materials, the hormone
Assay: 99%
Product Name: Tamoxifen citrate
Synonyms: terimon;trans-1-(p-beta-dimethylaminoethoxyphenyl)-1,2-diphenylbut-1-enecitrate;y-1,2,3-propanetricarboxylate(1:1);z-tamoxifencitrate;Z-1-(P-DIMETHYLAMINOETHOXYPHENYL)-1,2-DIPHENYL-1-BUTENE CITRATE;[Z]-1-[P-DIMETHYLAMINOETHOXYPHENYL]-1,2-DIPHENYL-1-BUTENE CITRATE SALT;(z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxyl]-n,n-dimethyl-ethanamine-citrate;(Z)-2-[4-(1,2-DIPHENYL-1-BUTENYL)PHENOXY]-N,N-DIMETHYLETHANAMINE CITRATE
CAS: 54965-24-1
MF: C32H37NO8
MW: 563.64
EINECS: 259-415-2
Product Categories: API;SOLTAMOX;-;Inhibitors;Active Pharmaceutical Ingredients;Antitumors for Research and Experimental Use;Biochemistry;API's;Intracellular receptor;Steroid and Hormone
Mol File: 54965-24-1.mol
Tamoxifen citrate Structure
Tamoxifen citrate Chemical Properties
Melting point 140-144 °C
storage temp. 2-8°C
solubility methanol: soluble50mg/mL, clear, colorless
form Powder
color White to off-white
Water Solubility slightly soluble
Sensitive Light Sensitive & Hygroscopic
Merck 14,9048
CAS DataBase Reference 54965-24-1(CAS DataBase Reference)
Anti Estrogen Steroids Nolvadex / Tamoxifen Citrate For Steroid Cycle Post Cycle Therapy ( PCT) 54965-24-1
Tamoxifen citrate Usage And Synthesis
Overview Tamoxifen, sold under the brand name Nolvadex among others, is a medication that is used to prevent breast cancer in women and treat breast cancer in women and men. The introduction of the anti-oestrogen tamoxifen in the early 1970s represented a landmark in the treatment of breast cancer. Over 40 years later, tamoxifen has been shown to be effective not only for early and advanced breast cancer, but also for ductal carcinoma in situ (DCIS) and the chemoprevention of breast cancer in high-risk pre- and post- menopausal women. Indeed, tamoxifen is the benchmark against which newer endocrine therapies continue to be measured.
Breast cancer is the second highly pervasive cause of mortalities in the world[1]. It does not cover only women but also men and food animals. Metastatic breast cancer is more drastic as the main causative agent is not known. Although, multiple causes have been known to be involved in the metastatic breast cancer, but still chemotherapy is a question to absolutely treat this cancer[1]. 1.3 million women suffer from breast cancer in United States. Similarly 1 out of every 7 women had breast cancer. Not only humans but also animals become victim of breast cancer. Tamoxifen was introduced by AstraZeneca of UK for the first time and being frequently prescribed as hormonal therapy for estrogen positive breast cancer in the clinics of Pakistan and Australia. It is far better to use right medicine with right dose at the right stage of the disease to opt maximum curative results. The exact kinetic and dynamic mechanism within human is necessary for manufacturing a drug against any disease.
Anti Estrogen Steroids Nolvadex / Tamoxifen Citrate For Steroid Cycle Post Cycle Therapy ( PCT) 54965-24-1
Figure 1 the chemical structure of Tamoxifen
Application Long term use of Tamoxifen as prophylaxis is recommended and found useful with decrease in recurrence rate of breast cancer. The risk-lowering effect of Tamoxifen appears to persist for at least 10 years, yet most side effects of Tamoxifen do not continue after the 5-year treatment period. Thus the long term treatment with Tamoxifen is appreciated[4]. Tamoxifen has been the adjuvant therapy of choice for postmenopausal, node-positive, and estrogen or progesterone receptor positive women since the mid-1980s, and for postmenopausal, node-negative, and estrogen or progesterone receptor-positive women since the early 1990s. It is also being used in many cases of node-negative and receptor-positive premenopausal women. A high proportion (40-60%) of all women who undergo potentially curative surgery for breast cancer now receive adjuvant Tamoxifen therapy for a period of 2 to 5 years. It was first approved for pharmaceutical use in the United Kingdom in 1973 and in the United States in 1977; Tamoxifen is presently registered in 97 countries. Tamoxifen use has been estimated at more than 7 million patient/years. The usual dose in the United States and the United Kingdom is 20 mg/day for 1 to 2 years whereas in continental Europe, usual doses are 30 to 40 mg/day[5].
Tamoxifen is used for the treatment of invasive breast cancer in men and women, the most common type of breast cancer, following surgery and/or radiation and for preventing invasive breast cancer in women at high risk for developing it. Tamoxifen also is used for the treatment of women following surgery and radiation for a less common type of breast cancer called ductal carcinoma in situ (DCIS or Intraductal Carcinoma). Women who have had DCIS are at high risk for developing invasive breast cancer at a later date, and tamoxifen prevents development of the invasive cancer in almost half of the women during the first five years of treatment. Occasionally, tamoxifen is used to stimulate ovulation.
Mode of action Tamoxifen is being frequently prescribed as hormonal therapy of estrogen positive breast cancer in the clinics of Pakistan. There is a competitive binding of tamoxifen to estrogen receptors in cancer cells and other tissue targets, and this in turn produces a nuclear complex that decreases DNA synthesis and inhibits estrogen action. It is a non-steroidal agent with potential anti estrogenic abilities which occupies estrogen binding sites in breast tissue and metabolized by the liver enzyme Cyp2D6 (cytochrome P450, family 2, subfamily D, polypeptide 6), rendering active metabolites of Tamoxifen includes N-desmethyl tamoxifen, endoxifen and 4 hydroxy tamoxifen[2]. Tamoxifen is known as a classic pro-drug requiring metabolic activation to start its pharmacological activity. Mainly 2D6 of cytochrome 450 appears to be the rate-limiting enzyme converting the pharmacologically inactive metabolites (Tamoxifen and NDM) to endoxifen, and further contributes to the formation of 4-OH-Tam from Tamoxifen. The findings depict that both genetic and environmental (drug-induced) factors that change CYP2D6 enzyme activity affect Tamoxifen treatment results[2]. Research was done to check the breast density after use of Tamoxifen in patients. MRI of breast was performed after Tamoxifen use. It was concluded that with the use of Tamoxifen breast cancer is reduced hence the breast density came out to be less[3].
Anti Estrogen Steroids Nolvadex / Tamoxifen Citrate For Steroid Cycle Post Cycle Therapy ( PCT) 54965-24-1

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