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|Product Name:||Coluracetam||Other Name:||Coluracetam|
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Coluracetam (INN) (code name BCI-540; formerly MKC-231) is a nootropic agent of the racetam family. It was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease. After the drug failed to reach endpoints in its clinical trials it was in-licensed by BrainCells Inc for investigations into major depressive disorder (MDD), which was preceded by being awarded a "Qualifying Therapeutic Discovery Program Grant" by the state of California. Findings from phase IIa clinical trials have suggested that it would be a potential medication for comorbidMDD with generalized anxiety disorder (GAD). BrainCells Inc is currently[when?] out-licensing the drug for this purpose.[full citation needed] It may also have potential use in prevention and treatment of ischemic retinopathy andretinal and optic nerve injury.[medical citation needed]
Coluracetam has been shown to reverse the loss of choline acetyltransferase production in the medial septal nucleus of rats exposed to phencyclidine (PCP), and is considered a potential therapeutic drug for schizophrenia.
|COLURACETAM Basic information|
|Synonyms:||COLURACETAM;N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide;1-Pyrrolidineacetamide,2-oxo-N-(5,6,7,8-tetrahydro-2,3-dimethylfuro[2,3-b]quinolin-4-yl)-;Coluracetam, MKC-231;1-[N-(2,3-DiMethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)carbaMoylMethyl]pyrrolidin-2-one;BCI-540;Coluracetam, >=99%;2-oxo-N-(5,6,7,8-tetrahydro-2,3-dimethyl-furo[2,3-b]quinolin-4-yl)-1-pyrrolidineacetamide|
|Product Categories:||Brain health drug;Nootropic;pharmaceutical intermediate or medicine grade|
Coluracetam is a fairly new nootropic compound, which is part of the racetam family. Because of how new it is, there are relatively few studies regarding the efficacy of the drug. Yet, what does exist is extremely promising for anyone interested in improving their memory, protecting their brain from neurological degeneration, and improving cognitive abilities.
The primary benefit of coluracetam is the increase in high affinity choline uptake (HACU) . More specifically, this process helps increase the uptake of choline into the synapses of the brain in order to synthesize more acetylcholine. Usually, human brains have limitations on acetylcholine production and coluracetam bypasses this for your cognitive benefit.
The downstream effects of this are manifold. One of the main proposed coluracetam benefits is as a neuroprotective agent that can support against Alzheimer’s disease . While the research is still scarce, this seems plausible given the interactions with the cholinergic system and these age-related neurological diseases.
Anecdotal evidence suggests that coluracetam, like some of the other racetams, can act as a mood enhancer as well. This evidence comes through nootropic communities as many people take the drug for cognitive enhancement and note the secondary effects. View the Selected Community Experiences below to see how people are reacting to coluracetam itself.
As explained before, coluracetam primarily works through the process of high affinity choline uptake. This is the “mechanism of action”, which is a fancy way of saying “how it works”. The brain chemical often responsible for storing memories and cognitive abilities is acetylcholine. This chemical is part of the cholinergic system, which is impacted when coluracetam increases the amount of acetylcholine in the brain.
As many studies on acetylcholine show, additional quantities of this brain chemical can prove very valuable for improving memory formation, learning, and general cognitive abilities. Coluracetam works by increasing your levels of acetylcholine in certain regions (such as the hippocampus), which are responsible for memory .
Again, the scientific research and evidence is scarce regarding the side effects of coluracetam. This nootropic compound is anecdotally well received by the human body and brain. Taking coluracetam usually does not create many side effects, but when they exist are similar to other racetams.
Irritability and nausea are sometimes concerns, but they are extremely rare. Usually coluracetam helps feelings of anxiety and depression. Finally, you might find that the coluracetam is too stimulating to take later in the evening or at night. If this is the case, just try to take it earlier or find a smaller dosage.
The research does not clearly state the best coluracetam dosage, but there are a few different recommendations based on extrapolating data. Taking a dose of 3.2 – 32.7 mg is recommended, but usually 20 mg is the starting dose.
One thing many people enjoy is to dose coluracetam sublingually, which helps to avoid first-pass metabolism in the intestinal tract. If using the sublingual solution, use a dosage of 20 mg to start and place the dropper under the tongue. The longer the solution is there, the better chance of absorption.
Keep in mind that the coluracetam dosage peaks in the blood at around 30 minutes, which means it is a fast-acting nootropic compound. In order to take advantage of it best, time your dosage for rigorous mental work as it declines from the bloodstream in 3 hours or less
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