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CAS 1379686-29-9 SR9011 For Muscle Building And Enhance Endurance Sarms

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CAS 1379686-29-9 SR9011 For Muscle Building And Enhance Endurance Sarms

China CAS 1379686-29-9 SR9011 For Muscle Building And Enhance Endurance Sarms supplier

Large Image :  CAS 1379686-29-9 SR9011 For Muscle Building And Enhance Endurance Sarms

Product Details:

Place of Origin: China
Brand Name: Pharmasupply
Certification: GMP; ISO; SGS
Model Number: Sarms Raw Powder

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Minimum Order Quantity: 10 G
Price: 295 USD / 10G
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Supply Ability: 1000kg/mouth
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Detailed Product Description
Product Name: SR9011 Other Name: SR-9011
Packaging: Foil Bag Or Vial Form: Powder
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CAS 1379686-29-9 SR9011 For Muscle Building And Enhance Endurance Sarms

 

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CAS 1379686-29-9 SR9011 For Muscle Building And Enhance Endurance Sarms

 

 

Product Name: SR9011
CAS: 1379686-29-9
MF: C23H31ClN4O3S
MW: 479.03524
Type: Analysis reagent
Grade: Medicine Grade
Standard: USP
Apprarance: White powder


Application:


SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV-ERB-α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism.

Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure.

Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic

 

 

SR9009 VS SR9011

 

SR9009 and SR9011 are attractive as performance-enhancing substances due to their REV-ERB agonist effects and thus circadian rhythm modulation activity. Although no pharmaceutical preparations are available yet, illicit use of SR9009 and SR9011 for doping purposes can be anticipated, especially since SR9009 is marketed in illicit products. Therefore, the aim was to identify potential diagnostic metabolites via in vitro metabolic studies to ensure effective (doping) control. The presence of SR9009 could be demonstrated in a black market product purchased over the Internet. Via human liver microsomal metabolic assays, eight metabolites were detected for SR9009 and fourteen metabolites for SR9011 by liquid chromatography–high resolution mass spectrometry (LC–HRMS). Structure elucidation was performed for all metabolites by LC–HRMS product ion scans in both positive and negative ionization mode. Retrospective data analysis was applied to 1511 doping control samples previously analyzed by a full-scan LC–HRMS screening method to verify the presence of SR9009, SR9011 and their metabolites. So far, the presence of neither the parent compound nor the metabolites could be detected in routine urine samples. However, to further discourage use of these potentially harmful compounds, incorporation of SR9009 and SR9011 into screening methods is highly recommended.

 

Keywords: REV-ERB agonists, SR9009, SR9011, phase I metabolism, in vitro studies, liquid chromatography–high resolution mass spectrometry (LC–HRMS), doping agents

 

 

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CAS 1379686-29-9 SR9011 For Muscle Building And Enhance Endurance Sarms
 
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SARMs List
MK-2866 (Ostarine)
RAD-140 (Testolone)
MK-677 (Ibutamoren; Nutrobal)
LGD-4033 (Ligandrol; Anabolicum)
S4 (Andarine)
SR9009 (Stenabolic)
SR9011
YK11
GW501516 (Cardarine) / GSK-516)
AICAR
S-23
LGD-3303
GW-0742
MK-1775
ACP-105

 
 
CAS 1379686-29-9 SR9011 For Muscle Building And Enhance Endurance Sarms

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