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Estrogen Depo Estradiol / Estradiol Cypionate / EC Steroid Powder For Veterinary CAS 313-06-4

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Estrogen Depo Estradiol / Estradiol Cypionate / EC Steroid Powder For Veterinary CAS 313-06-4

China Estrogen Depo Estradiol / Estradiol Cypionate / EC Steroid Powder For Veterinary CAS 313-06-4 supplier

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Place of Origin: Hubei, China
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Certification: ISO9001, USP, BP, GMP
Model Number: steroid hormone raw powder

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Name: Estradiol Cypionate Appearance: Powder
Assay: 99% Min. MOQ: 10g
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Estrogen Depo-Estradiol / Estradiol Cypionate / EC Steroid Powder For Veterinary Use CAS 313-06-4




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Estradiol Cypionate

Estradiol cypionate (EC), sold under the brand name Depo-Estradiol among others, is an estrogen medication which is used in hormone therapy for menopausal symptoms and low estrogen levels in women, in hormone therapy for transgender women, and in hormonal birth control for women.[10][4][12][13] It is given by injection into muscle once every 1 to 4 weeks.[10][11]

Side effects of estradiol cypionate include breast tenderness, breast enlargement, nausea, headache, and fluid retention.[10][4]Estradiol cypionate is a synthetic estrogen and hence is an agonist of the estrogen receptor (ER), the biological target of estrogens like estradiol.[4][3] Estradiol cypionate is an estrogen ester and a long-lasting prodrug of estradiol in the body.[10][4][3] Because of this, it is considered to be a natural and bioidentical form of estrogen.[3][14][15]

Estradiol cypionate was first described as well as introduced for medical use in 1952.[16][17] Along with estradiol valerate, it is one of the most commonly used esters of estradiol.[18] Estradiol cypionate has mostly been used in the United States, but is also marketed in a few other countries.[19][20][21] The medication is not available in Europe.[22] It is not currently available as a generic medication in the United States

Product name:Estradiol Cypionate;Depofemin;Depo-Estradiol
Density:1.15g / cm3
Boiling point:532.8 ° C at 760 mmHg
Flash Point: 207.7 ° C
Vapor Pressure:5.73E-12mmHg at 25 ° C
Assay: 0.99
Specification: USP/BP
Appearance: White crystalline powder
Estrogen Depo Estradiol / Estradiol Cypionate / EC Steroid Powder For Veterinary CAS 313-06-4
Estrogens direct the development of the female genotype in embryogenesis and at puberty. Estradiol is the major
estrogen secreted by the premenopausal ovary. Estradiol benzoate is an estradiol analog which contains a benzyl
ester at the C-3 position and is often used in combination with a progestin to induce estrus in domestic livestock.
This compound binds to the human and murine estrogen receptor α (ERα), and chicken ER with IC50 values in
the range of 22-28 nM. This reflects a 6-10 fold reduction in binding affinity compared to estradiol.
Estradiol cypionate , or estradiol cipionate, is a synthetic ester, specifically the 3-cyclopentylpropanoyl ester, of the natural estrogen, estradiol. It was first introduced in 1952 by Upjohn in the United States, and has been in widespread use since. Estradiol cypionate is absorbed more slowly than estradiol itself, and for that reason, it can be administered less often.Compared to other commonly used estradiol esters, via the intramuscular route, estradiol cypionate was found to have the longest duration of action with a duration of ~11 days, while estradiol benzoate and estradiol valerate were found to last for 4-5 days and 7-8 days, respectively.
Estradiol is produced especially within the follicles of the female ovaries, but also in other endocrine (i.e., hormone-producing) and non-endocrine tissues (e.g., including fat, liver, adrenal, breast, and neural tissues). Estradiol is biosynthesized from progesterone (arrived at in two steps from cholesterol, via intermediate pregnenolone). One principal pathway then converts progesterone to its 17-hydroxy derivative, 17-Hydroxyprogesterone, and then to 4-androstenedione via sequential cytochrome P450-catalyzed oxidations.[citation needed] Action of aromatase on 4-androstenedione generates estrone, and action of a dehydrogenase on this gives the title compound, 17β-estradiol.[citation needed] Alternatively, 4-androstenedione can be converted into the androgen, testosterone, which in turn can be converted directly into 17β-estradiol.


Dementia, geriatric

Hormone replacement therapy (HRT), both estrogen/progestin combination therapy and estrogen alone therapy, has been found to fail to prevent mild cognitive impairment (memory loss) and to increase the risk of dementia in geriatric women 65 years and older. Administration of HRT should generally be avoided in women 65 years of age and older, and HRT should not be used to prevent or treat dementia or preserve cognition (memory). Overall risk vs. benefit should be considered along with the goals of use of HRT for the individual patient when considering whether to continue HRT in a geriatric woman over 65 years of age. According to the Beers Criteria, oral and topical patch, or other systemic forms of estrogens, with or without progestins are considered potentially inappropriate medications (PIMs) for use in geriatric patients and should be avoided due to evidence of carcinogenic potential (i.e., breast and endometrium) and lack of cardiovascular or cognitive protective effects in older women. Additionally, the Beers expert panel recommends avoiding oral or transdermal estrogen in elderly women with any type of urinary incontinence due to the potential for aggravation of incontinence. The Beers expert panel considers use of intra-vaginal preparations acceptable for the management of dyspareunia, lower urinary tract infections, and other vaginal/vulvar symptoms. In addition, evidence suggests that vaginal estrogens are safe and effective for the treatment of vaginal dryness; women with a history of breast cancer who do not respond to non-hormonal therapies are advised to discuss the risks and benefits of low-dose vaginal estrogen (estradiol less than 25 mcg twice weekly) with their healthcare provider. The federal Omnibus Budget Reconciliation Act (OBRA) regulates medication use in residents of long-term care facilities (LTCFs). According to the OBRA guidelines, assessment of the underlying causes and identification of the type/category of urinary incontinence needs to be documented prior to or soon after initiating treatment with a medication to manage urinary incontinence (e.g., estrogen replacement agents). These medications have specific and limited indications based on the cause and categorization of incontinence. Patients should be assessed periodically for medication effects on urinary incontinence as well as lower urinary tract symptoms and treatment tolerability. The Guidelines caution that oral estrogen products may cause systemic side effects and increased risks (e.g., DVT, breast cancer), and topical agents may be preferred.


Accidental exposure

Estradiol is available in many topical dosage forms, including transdermal systems, topical emulsions, topical gels, and topical sprays. Estradiol topical gels and sprays are alcohol-based and thus are potentially flammable. Patients should be advised to avoid fire, flame, or smoking until the gel or spray has dried after application. Patients should be advised to carefully read and follow administration directions in order to avoid accidental exposure of estradiol hormone to others, including children and pets. In July 2010, the FDA released an advisory notice warning of inadvertent exposure to Evamist brand topical spray through skin contact with patients using the product. Adverse events including premature puberty, nipple swelling and breast development in females, and breast enlargement in males were reported. Reports of pet exposure were also reported; signs of exposure in pets may include mammary/nipple enlargement and vulvar swelling. To reduce the risk of exposure, patients applying this product should avoid contact of the treated area to children and pets. If direct contact cannot be avoided, the treated area should be covered with a garment. If inadvertent exposure occurs, the skin of the child or pet should be washed immediately with soap and water. Patients should be aware that if a child under their care shows signs of exposure including breast development or other sexual changes, the child should be examined by a healthcare professional. Once exposure is removed, symptoms of exposure should resolve.

Estrogen Depo Estradiol / Estradiol Cypionate / EC Steroid Powder For Veterinary CAS 313-06-4



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Estrogen Depo Estradiol / Estradiol Cypionate / EC Steroid Powder For Veterinary CAS 313-06-4

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