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Local Anesthetic Agent Lidocaine Base Surface Anesthesia Lidocaine Powder For Pain Relif 137-58-6

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Local Anesthetic Agent Lidocaine Base Surface Anesthesia Lidocaine Powder For Pain Relif 137-58-6

China Local Anesthetic Agent Lidocaine Base Surface Anesthesia Lidocaine Powder For Pain Relif 137-58-6 supplier

Large Image :  Local Anesthetic Agent Lidocaine Base Surface Anesthesia Lidocaine Powder For Pain Relif 137-58-6

Product Details:

Place of Origin: China
Brand Name: saichuang
Certification: GMP; ISO; SGS
Model Number: Pain Killer Powder

Payment & Shipping Terms:

Minimum Order Quantity: 10 vials
Price: USD1/10g~USD100/10g
Packaging Details: vial and foil bag
Delivery Time: Within 24hours after received your payment
Payment Terms: Western Union, T/T, Money Gram, Paypal
Supply Ability: 1000kg/mouth
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Detailed Product Description
Product Name: Lidocaine Other Name: Lidocaine Base
Number: 137-58-6 M.F.: C14h23n2o
Packaging: Foil Bag Or Vial Appearance: White Crystalline Powder
Assays: 99% Shipping: By Express (FedEx,UPS,DHL,EMS), By Air And By Sea
Payment: Estern Union, Money Gram, T/T And Paypal WhatsAPP: +8618873306038
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local anesthetic powder

Local Anesthetic Agent Lidocaine Base Surface Anesthesia Lidocaine Powder For Pain Relif 137-58-6

 

 

description Lidocaine is a local anesthetic, also known as Xylocaine, in recent years it has been replaced procaine, widely used in local infiltration anesthesia in cosmetic plastic surgery, it can block the nerve excitability and conduction by inhibiting the sodium channels of nerve cell membrane. The fat soluble and protein binding rate of lidocaine is higher than procaine, its cell penetrating ability is strong, fast onset, long duration of action, the interaction strength is 4 times of procaine.
Lidocaine is used in infiltration anesthesia, epidural anesthesia, topical anesthesia (including thoracoscopy or abdominal surgery for mucosal anesthesia) and nerve block. In order to extend the time of anesthesia, reduce the poisoning of lidocaine and other side effects, can be added in the anesthetic epinephrine.
Lidocaine can also be used for the treatment of ventricular premature beat after acute myocardial infarction, ventricular tachycardia, digitalis poisoning, cardiac surgery and cardiac catheterization-induced ventricular arrhythmias, including ventricular premature beats, ventricular tachycardia and ventricular fibrillation. Lidocaine is also used for duration status of epilepsy which other anti-seizure drugs are not effective, as well as local or spinal anesthesia. But it is usually ineffective for supraventricular arrhythmias.

 

 

Product Details
product Name Lidocaine
Synonyms 2-(Diethylamino)-N-(2,6-dimethylphenyl)-acetamide; Lignocaine; 2-diethylaminoacet-2,6-xylidide; Xylocaine; N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide; 2-[(2,6-dimethylphenyl)amino]-N,N-diethyl-2-oxoethanaminium
Molecular Formula C14H23N2O
Molecular Weight 235.3447
InChI InChI=1/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)/p+1
Registry Number 137-58-6
EINECS 205-302-8

 

Lidocaine is white needle like crystals, and its melting point is 68-69℃; boiling point is 180-182℃ (0.53kPa), soluble in ethanol in 159-160℃ (0.267kPa), ether, benzene, chloroform and oil, do not dissolve in water. In common use radical hydrochloride, lidocaine hydrochloride (C14H22N2O • HCL, [73-78-9]) is a white crystalline powder. Melting point 127-129℃, and the monohydrate melting point is 77-78℃. Easily soluble in water, 0.5% aqueous solution pHO 4.0-5.5. Odorless, bitter taste.

 

 

 

Product Name: Lidocaine
Synonyms: Acetamide,2-(diethylamino)-N-(2,6-dimethylphenyl)-;a-Diethylamino-2,6-acetoxylidide;alfa-Dietilamino-2,6-dimetilacetanilide;alpha-(Diethylamino)-2,6-acetoxylidide;alpha-diethylamino-2,6-acetoxylidide;alpha-Diethylamino-2,6-dimethylacetanilide;alpha-Diethylaminoaceto-2,6-xylidide;Anbesol
CAS: 137-58-6
MF: C14H22N2O
MW: 234.34
EINECS: 205-302-8
Product Categories: Research Chemical;Alphacaine, Xylocaine, lignocaine;REGITINE;Other APIs;Pharma materials;API;Halogenated Heterocycles
Mol File: 137-58-6.mol
Lidocaine Structure



Specifications:

Test Items Specification Test Results
Description White or almost white crystalline powder White crystalline powder
Melting Point 191.0~193.0ºC 192ºC
Loss of drying ≤1.0% 0.5%
Heavy Metal ≤20ppm 15ppm
TLC Only one spot Only one spot
Assay ≥99.5% 99.91%
Conclusion It complies with the USP 32.


Local Anesthetic Agent Lidocaine Base Surface Anesthesia Lidocaine Powder For Pain Relif 137-58-6

Applications:


The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and surface anesthesia. Longer-acting substances such asbupivacaine are sometimes given preference for subdural and epidural anesthesias; lidocaine, though, has the advantage of a rapid onset of action. Epinephrine (adrenaline) vasoconstricts arteries, reducing bleeding and also delays the resorption of lidocaine, almost doubling the duration of anaesthesia. For surface anesthesia, several available formulations can be used e.g. for endoscopies, before intubations, etc. Buffering the pH of lidocaine makes local freezing less painful.Lidocaine drops can be used on the eyes for short ophthalmic procedures.
Topical lidocaine has been shown in some patients to relieve the pain of postherpetic neuralgia (a complication of shingles), though not enough study evidence exists to recommend it as a first-line treatment.ntravenous lidocaine also has uses as a temporary fix for tinnitus. Although not completely curing the disorder, it has been shown to reduce the effects by around two-thirds.
Lidocaine is also the most important class-1b antiarrhythmic drug; it is used intravenously for the treatment of ventricular arrhythmias (for acute myocardial infarction, digoxin poisoning, cardioversion, or cardiac catheterization) if amiodarone is not available or contraindicated. Lidocaine should be given for this indication after defibrillation, CPR, and vasopressors have been initiated. A routine prophylactic administration is no longer recommended for acute cardiac infarction; the overall benefit of this measure is not convincing.
Inhaled lidocaine can be used as an antitussive (cough suppressor) acting peripherally to reduce the cough reflex. This application can be implemented as a safety and comfort measure for patients who have to be intubated, as it reduces the incidence of coughing and any tracheal damage it might cause when emerging from anesthesia.
Lidocaine, along with ethanol, ammonia, and acetic acid, has also been proven to be effective in treating jellyfish stings, both numbing the affected area and preventing further nematocyst discharge.

 

Local Anesthetic Agent Lidocaine Base Surface Anesthesia Lidocaine Powder For Pain Relif 137-58-6

 

 

Lidocaine Chemical Properties
Melting point 66-69°C
Boiling point bp4 180-182°; bp2 159-160°
density 0.9944 (rough estimate)
refractive index 1.5110 (estimate)
Fp 9℃
storage temp. Store at RT
solubility ethanol: 4 mg/mL
form powder
pka pKa 7.88(H2O)(Approximate)
color White to slightly yellow
Water Solubility practically insoluble
Merck 14,5482
Stability:

Stable. Incompatible with strong oxidizing agents.

 

 

Chemical Properties solid
Uses Lidocaine (Alphacaine)is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. [1] Histamine is responsible for many features of allergic reactions. Lidocaine (Alphacaine)is a second-generation antihistamine agent closely st
Uses antihypertensive
Uses Anticonvulsant
Uses Antiarrhythmic Agents, Anesthetics


Local Anesthesia

Benzocaine Prilocaine Propitocaine hydrochloride
Bupivacaine Tetracaine Proparacaine hydrochloride
Lidocaine Tetracaine hydrochloride Bupivacaine hydrochloride
Linocaine hydrochloride Pramoxine hydrochloride Dibucaine hydrochloride
Procaine Articaine hydrochloride Ropivacaine hydrochloride
Procaine hydrochloride Benzocaine hydrochloride Levobupivacaine Hcl

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