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|Product Name:||Lidocaine||Other Name:||Lidocaine Base|
|Packaging:||Foil Bag Or Vial||Appearance:||White Crystalline Powder|
|Assays:||99%||Shipping:||By Express (FedEx,UPS,DHL,EMS), By Air And By Sea|
|Payment:||Estern Union, Money Gram, T/T And Paypal||WhatsAPP:||+8618873306038|
topical anesthetic drugs,
local anesthetic powder
Local Anesthetic Agent Lidocaine Base Surface Anesthesia Lidocaine Powder For Pain Relif 137-58-6
|description||Lidocaine is a local anesthetic, also known as Xylocaine, in recent years it has been replaced procaine, widely used in local infiltration anesthesia in cosmetic plastic surgery, it can block the nerve excitability and conduction by inhibiting the sodium channels of nerve cell membrane. The fat soluble and protein binding rate of lidocaine is higher than procaine, its cell penetrating ability is strong, fast onset, long duration of action, the interaction strength is 4 times of procaine.
Lidocaine is used in infiltration anesthesia, epidural anesthesia, topical anesthesia (including thoracoscopy or abdominal surgery for mucosal anesthesia) and nerve block. In order to extend the time of anesthesia, reduce the poisoning of lidocaine and other side effects, can be added in the anesthetic epinephrine.
Lidocaine can also be used for the treatment of ventricular premature beat after acute myocardial infarction, ventricular tachycardia, digitalis poisoning, cardiac surgery and cardiac catheterization-induced ventricular arrhythmias, including ventricular premature beats, ventricular tachycardia and ventricular fibrillation. Lidocaine is also used for duration status of epilepsy which other anti-seizure drugs are not effective, as well as local or spinal anesthesia. But it is usually ineffective for supraventricular arrhythmias.
product Name Lidocaine
Synonyms 2-(Diethylamino)-N-(2,6-dimethylphenyl)-acetamide; Lignocaine; 2-diethylaminoacet-2,6-xylidide; Xylocaine; N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide; 2-[(2,6-dimethylphenyl)amino]-N,N-diethyl-2-oxoethanaminium
Molecular Formula C14H23N2O
Molecular Weight 235.3447
Registry Number 137-58-6
Lidocaine is white needle like crystals, and its melting point is 68-69℃; boiling point is 180-182℃ (0.53kPa), soluble in ethanol in 159-160℃ (0.267kPa), ether, benzene, chloroform and oil, do not dissolve in water. In common use radical hydrochloride, lidocaine hydrochloride (C14H22N2O • HCL, [73-78-9]) is a white crystalline powder. Melting point 127-129℃, and the monohydrate melting point is 77-78℃. Easily soluble in water, 0.5% aqueous solution pHO 4.0-5.5. Odorless, bitter taste.
|Product Categories:||Research Chemical;Alphacaine, Xylocaine, lignocaine;REGITINE;Other APIs;Pharma materials;API;Halogenated Heterocycles|
|Test Items||Specification||Test Results|
|Description||White or almost white crystalline powder||White crystalline powder|
|Loss of drying||≤1.0%||0.5%|
|TLC||Only one spot||Only one spot|
|Conclusion||It complies with the USP 32.|
The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and surface anesthesia. Longer-acting substances such asbupivacaine are sometimes given preference for subdural and epidural anesthesias; lidocaine, though, has the advantage of a rapid onset of action. Epinephrine (adrenaline) vasoconstricts arteries, reducing bleeding and also delays the resorption of lidocaine, almost doubling the duration of anaesthesia. For surface anesthesia, several available formulations can be used e.g. for endoscopies, before intubations, etc. Buffering the pH of lidocaine makes local freezing less painful.Lidocaine drops can be used on the eyes for short ophthalmic procedures.
Topical lidocaine has been shown in some patients to relieve the pain of postherpetic neuralgia (a complication of shingles), though not enough study evidence exists to recommend it as a first-line treatment.ntravenous lidocaine also has uses as a temporary fix for tinnitus. Although not completely curing the disorder, it has been shown to reduce the effects by around two-thirds.
Lidocaine is also the most important class-1b antiarrhythmic drug; it is used intravenously for the treatment of ventricular arrhythmias (for acute myocardial infarction, digoxin poisoning, cardioversion, or cardiac catheterization) if amiodarone is not available or contraindicated. Lidocaine should be given for this indication after defibrillation, CPR, and vasopressors have been initiated. A routine prophylactic administration is no longer recommended for acute cardiac infarction; the overall benefit of this measure is not convincing.
Inhaled lidocaine can be used as an antitussive (cough suppressor) acting peripherally to reduce the cough reflex. This application can be implemented as a safety and comfort measure for patients who have to be intubated, as it reduces the incidence of coughing and any tracheal damage it might cause when emerging from anesthesia.
Lidocaine, along with ethanol, ammonia, and acetic acid, has also been proven to be effective in treating jellyfish stings, both numbing the affected area and preventing further nematocyst discharge.
|Lidocaine Chemical Properties|
|Boiling point||bp4 180-182°; bp2 159-160°|
|density||0.9944 (rough estimate)|
|refractive index||1.5110 (estimate)|
|storage temp.||Store at RT|
|solubility||ethanol: 4 mg/mL|
|color||White to slightly yellow|
|Water Solubility||practically insoluble|
Stable. Incompatible with strong oxidizing agents.
|Uses||Lidocaine (Alphacaine)is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.  Histamine is responsible for many features of allergic reactions. Lidocaine (Alphacaine)is a second-generation antihistamine agent closely st|
|Uses||Antiarrhythmic Agents, Anesthetics|
|Lidocaine||Tetracaine hydrochloride||Bupivacaine hydrochloride|
|Linocaine hydrochloride||Pramoxine hydrochloride||Dibucaine hydrochloride|
|Procaine||Articaine hydrochloride||Ropivacaine hydrochloride|
|Procaine hydrochloride||Benzocaine hydrochloride||Levobupivacaine Hcl|
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