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topical anesthetic drugs,
local anesthetic powder
Product Name: Benzocaine
Synonyms: 4-AMINOBENZOIC ACID ETHYL ESTER;AETHOFORM;AKOS BBS-00003658;anesthesin;auralgan otic;BENZOCAINE;benzocaine bp98;BENZOCAINUM;ETHYL 4-AMINOBENZOATE;ethyl aminobenzoate;ETHYLAMINOBENZOATE-4;ETHYL P-AMINOBENZOATE;H-4-ABZ-OET;LABOTEST-BB LTBB000527;ORTHESIN;P-AMINOBENZOIC ACID ETHYL ESTER;parathesin;4-(Ethoxycarbonyl)aniline;4-amino-benzoicaciethylester;4-Carbethoxyaniline ;;4-Aminobenzoic acid ethyl ester; benzocaine methanol solution; Ethyl 4-aminobenzoate,(4-Aminobenzoic acid ethyl ester); Benzocaine; H-4-Abz-OEt; Benzocione; 4-(ethoxycarbonyl)aniliniumato;
EINECS No.: 202-303-5
Molecular Formula: C9H11NO2
Molecular Weight: 165.19
Melting point: 88-90
Appearance: white crystalline powder
Standard: Enterprise Standard
Packing: 25KG/Drum or as per your requirements
Application: Cosmetic use & medical use
Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA). It can be prepared from PABA and ethanol by Fischer esterification or via the reduction of ethyl p-nitrobenzoate. Benzocaine is sparingly soluble in water; it is more soluble in dilute acids and very soluble in ethanol, chloroform and ethyl ether. The melting point of benzocaine is 88-90 째C, and the boiling point is about 310. The density of benzocaine is 1.17 g/cm3.
Benzocaine was first synthesized in 1890 by the German chemist Eduard Ritsert (1859-1946), in the town of Eberbach and introduced to the market in 1902 under the name "An채sthesin".
Benzocaine is indicated to treat a variety of pain-related conditions. It may be used for:
1. Local anesthesia of oral and pharyngeal mucous membranes (sore throat, cold sores, mouth ulcers, toothache, sore gums, denture irritation)
2. Otic Pain (earache)
3. Surgical or procedural local anesthesia
Benzocaine is generally well-tolerated and non-toxic when applied topically as recommended.
However, there have been reports of serious, life-threatening adverse effects (e.g., seizures, coma, irregular heart beat, respiratory depression) with over-application of topical products or when applying topical products that contain high concentrations of benzocaine to the skin.
Over-application of oral anesthetics such as benzocaine can increase the risk of pulmonary aspiration by relaxing the gag-reflex and allowing regurgitated stomach contents or oral secretions to enter the airway. Applying an oral anesthetic and consuming beverages before going to bed can be particularly hazardous.
The topical use of higher concentration (14-20%) benzocaine spray products applied to the mouth or mucous membranes has been found to be a cause of methemoglobinemia, a disorder in which the amount of oxygen carried by the blood is greatly reduced. side effect is most common in children under 2 years of age. As a result, the FDA has stated that benzocaine products should not be used in children under 2 years of age, unless directed by and supervised by a healthcare professional. Symptoms of methemoglobinemia usually occur minutes to hours of applying benzocaine, and can occur upon the first-time use or after additional use.
Ultraviolet absorption used in cosmetics, topical anesthetics, for the wound, ulcer pain and hemorrhoids.
Benzocaine is a local anesthetic commonly used as a topical pain reliever or in cough drops. It is the active ingredient in many over-the-counter anesthetic ointments such as products for oral ulcers. It is also combined with antipyrine to form A/B otic drops to relieve ear pain and remove earwax
Benzocaine is used as a key ingredient in numerous pharmaceuticals:
Over the counter throat lozenges such as Cepacol.
Some glycerol-based ear medications for use in removing excess wax as well as relieving ear conditions such as otitis media and swimmers ear.
Some previous diet products such as Ayds.
Some condoms designed to prevent premature ejaculation. Benzocaine largely inhibits sensitivity on the penis, and can allow for an erection to be maintained longer (in a continuous act) by delaying ejaculation. Conversely, an erection will also fade faster if stimulus is interrupted.
Benzocaine mucoadhesive patches have been used in reducing orthodontic pain.
In Poland it is included, together with menthol and zinc oxide, in the liquid powder (not to be confused with the liquid face powder) used mainly after mosquito stings. Today's ready made Pudroderm was once used there as pharmaceutical compound.
|Lidocaine||Tetracaine hydrochloride||Bupivacaine hydrochloride|
|Linocaine hydrochloride||Pramoxine hydrochloride||Dibucaine hydrochloride|
|Procaine||Articaine hydrochloride||Ropivacaine hydrochloride|
|Procaine hydrochloride||Benzocaine hydrochloride||Levobupivacaine Hcl|
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