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|Product Name:||Ru58841||Cas Number:||154992-24-2|
|Usage:||Anti Hair Loss|
steroid raw powder,
raw hormone powders
Purity 99% Pharmaceutical Raw Steroid Powders Ru58841 For Male Hairloss Treatment CAS 154992-24-2
Certificate:HACCP ISO KOSHER
Shelf life:2 years
What is RU-58841
RU-58841 (also known as PSK-3841 or HMR-3841) is a nonsteroidal antiandrogen (NSAA) which was previously investigated for use as a topical treatment for acne, androgenetic alopecia, and hirsutism. The compound is similar in structure to RU-58642 but contains a different side-chain. These compounds are similar in chemical structure to nilutamide, which is related to flutamide, bicalutamide, and enzalutamide. RU-58841 can be synthesized either by building the hydantoin moiety or by aryl coupling to 5,5-dimethylhydantoin.
RU58841 is used for the treatment of hair loss dwindled, perhaps due more to commercial potential and chemical stability reasons than efficacy as the later studies of RU58841 powder have focused on different chemical forms of the drug and combining it with various nanoparticles to enhance delivery.
RU-58841, also known as PSK-3841 or HMR-3841, is a nonsteroidal antiandrogen (NSAA) which was formerly under investigation by ProStrakan (previously ProSkelia and Strakan) for potential use as a topical treatment for androgen-dependent conditions including acne, pattern hair loss, and excessive hair growth. The compound is similar in structure to the NSAA RU-58642 but contains a different side-chain.These compounds are similar in chemical structure to nilutamide,which is related to flutamide, bicalutamide, and enzalutamide, all of which are NSAAs similarly.RU-58841 can be synthesized either by building the hydantoin moiety or by aryl coupling to 5,5-dimethylhydantoin.
RU-58841 produces cyanonilutamide (RU-56279) and RU-59416 as metabolites in animals. Cyanonilutamide has relatively low affinity for the androgen receptor but shows significant antiandrogenic activity in animals.RU-59416 has very low affinity for the androgen receptor.
RU 58841 is a specific androgen receptor antagonist or anti-androgen used as a topical treatment for acne, androgenetic alopecia and hirsutism. RU 58841 displays high affinity for the hamster prostate and flank organ (F.O.) androgen receptors. In vivo, when topically applied, it exerts a potent dose-dependent regression of F.O. area at a dose as low as 1 microgram/animal while being devoid of antiandrogenic activity on deep accessory sex organs and of any effect on testosterone level up to 100 micrograms/animal. RU 58841 has a dramatic effect on hair regrowth.
RU-58841 as a Possible Treatment for Hair Loss
RU58841 is considered to be one of the most promising drugs regarding hair loss prevention. To study the effect of the RU58841 on human hair growth, researchers (Brouwer et al., 1997) used twenty productive scalp grafts from balding men. The grafts that were treated with a solution of RU58841 had a total of 29 active follicles while the control grafts had two follicles.
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