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|Product Name:||AC-262536||Other Name:||AC-262536|
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selective androgen receptor modulators
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SARMs are synthetic ligands (usually non-steroidal) that ideally act as a full agonist on anabolic organs (creating desirable effects on muscle and bone).
AC-262536 is a non-steroidal androgen receptor (AR) agonist and in animal studies shows to be highly selective.
AC-262536 is a drug developed by Acadia Pharmaceuticals which acts as a selective androgen receptor modulator (SARM). Chemically it possesses endo-exo isomerism, with the endo form being the active form. It acts as a partial agonist for the androgen receptor with a Ki of 5nM, and no significant affinity for any other receptors tested. In animal studies it produced a maximal effect of around 66% of the anabolic action of testosterone, but only around 27% of its potency as anandrogen
Although it was initially discovered and studied in 2007, limited research has been conducted since and there are no human clinical studies to date.
However, initial animal studies show promise in a range of areas including building muscle growth, protecting against prostate cancer and improving Alzheimer’s Disease.
As with all SARMs, AC-262,536 works by activating muscle and bone androgen receptors rather than sexual tissue. The androgen receptor (AR) primarily targets normal human sexual development, but its activation by compounds (such as testosterone) also affects bone, muscle, liver and the central nervous system.
The problem within the medical and bodybuilding communities is that using testosterone to activate AR signaling for increased muscle and bone development also affects the sex tissues, resulting in testes shrinkage, prostate cancer risks and enlarged clitoris in females.
AC-262,536, a nonsteroidal selective androgen receptor modulator (SARM) bypasses this issue by binding to the androgen receptor.
This stimulation results in androgen receptor activation in bone and muscle cell, rather than raising liver enzymes or affecting sexual tissue.
Although studies are limited, there are 4 core benefits of supplementing with AC-262,536.
As with most SARMs, studies show that AC-262,536 does not appear to have any side effects common to steroidal compounds. Unlike testosterone, AC-262,536 does not cause prostate enlargement or testes shrinkage – in fact, it has been shown to suggest a decrease in prostate size.
However, as it is still in early developmental stages, this does not mean that there are no long-term effects. More research needs to be conducted on this compound.
As there have not been any human clinical studies to date, dosing recommendations come from individuals who have used AC-262,536 for performance and strength enhancing purposes.
10mg-30mg per day
Post Cycle Therapy (PCT) is required when taking SARMS to help preserve muscle gains, prevent fat accumulation, maintain mood and motivation, and retain strength in muscles. Cycling also helps to allow hormone levels to return to their natural state in order to prevent unwanted dependency.
Typically, a PCT will last the same duration as supplementation. So if a user supplemented with a hormone for 12 weeks, a PCT of 12 weeks would also be required to bring their hormones back to baseline.
But do I need a PCT when taking SARMs?
Because SARMs do not disrupt hormone levels in the body, a traditional PCT is not necessary. However, many users report taking a mini PCT such as a Test Booster for 4 weeks to ensure hormone levels are balanced.
Additionally, as AC-262,536 has not been clinically trialed on humans and has shown an indication to decrease LH levels, a PCT would be a good idea.
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