Payment & Shipping Terms:
|Product Name:||GW-0742||Other Name:||GW0742|
|Packaging:||Foil Bag Or Vial||Form:||Powder|
|Assays:||99%||Shipping:||By Express (FedEx,UPS,DHL,EMS), By Air And By Sea|
|Payment:||Western Union, Money Gram, T/T And Paypal||WhatsApp:||+8618873306038|
selective androgen receptor modulators
Keywords: GW 0742, GW 0742 supplier, selective, potent, PPARδ, PPARdelta, agonists, Peroxisome, Proliferator-activating, Receptors, GW0742, GlaxoSmithKline, GSK, 2229, Tocris Bioscience
GW 0742 Description:
The transcription factor peroxisome proliferator-activated receptor δ (PPARδ) is a member of the superfamily of nuclear hormone receptors and is implicated both in lipid metabolism and in the regulation of genes with potential roles in neurotoxicity. GW 0742 is a selective PPARδ agonist (EC50 = 1.1 nM) that exhibits 1,000-fold selectivity over the other human PPAR subtypes.1 GW 0742 exhibits time-dependent neuroprotection in low KCl-induced apoptosis in cerebellar granule neuronal cultures. Despite the neuroprotective properties observed, prolonged (48h) incubation with GW 0742 produced significant inherent toxicity. This cell death was determined to be apoptotic as identified with the TUNEL assay.2
Potent and highly selective PPARδ agonist. EC50 values are 0.001, 1.1 and 2 μM for transactivation of human PPARδ, -α, and -γreceptors respectively. Neuroprotective in rat cerebellar granule neuronal cultures after brief (12-hour) exposure but exhibits inherent toxicity after prolonged (48-hour) incubation. Increases rate of fatty acid oxidation and protects against ischemia/reperfusion injury in neonatal and adult cardiomyocytes.
Sold for research purposes under agreement from GlaxoSmithKline
GW0742 is a high affinity PPAR-β/δ agonist reduces lung inflammation induced by bleomycin instillation in mice.
A high throughput screening campaign was conducted to identify small molecules with the ability to inhibit the interaction between the vitamin D receptor (VDR) and steroid receptor coactivator
This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates,
|Storage||Desiccate at +4°C|
We're specialized in pharma.raw materials ( hormone steroid powders, Steroids injectable liquids,peptides,Sarms), our company integrates R&D, producing, operating and marketing into an organic whole. We have authority of export and import, and have experience of export for 15 years.
Major Market: United States, United Kingdom, Australia, Canada, Sweden, Russia, Poland, Brazil, Israel, Netherlands, Germany,Spain, Switzerland, Poland and so on.
Package:Disguised & Discreet pkg
Delivery: sent out the goods within 24hours after receiving payment.
Custom Pass rate:99%
Resend policy is available if the parcle is seized or any quality problems been found.
After-sale Service :
Discounts are available for our second-time customers. We can provide recipes and professional suggestions to promote yourselves. Tracking number and packing photos can be given quickly after your goods sent. We are always here waiting for you!
Our main products are wait for you:
Anabolic Steroid Powders
Semi-finished Steroid liquid
Male enhancement powder
Pain Killer Powders
Solvents for Steroids: BA, BB, GSO, Guaiacol, EO, PEG etc.
Tools & Devices: Filter,Crimper,Vials, caps, ect.
|MK-677 (Ibutamoren; Nutrobal)|
|LGD-4033 (Ligandrol; Anabolicum)|
|GW501516 (Cardarine) / GSK-516)|
Contact Person: Lin.z