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SARMS Powder GW0742 / GW 0742 / GW610742 PPAR Agonist CAS 1196133-39-7

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SARMS Powder GW0742 / GW 0742 / GW610742 PPAR Agonist CAS 1196133-39-7

China SARMS Powder GW0742 / GW 0742 / GW610742 PPAR Agonist  CAS 1196133-39-7 supplier

Large Image :  SARMS Powder GW0742 / GW 0742 / GW610742 PPAR Agonist CAS 1196133-39-7

Product Details:

Place of Origin: China
Brand Name: Pharmasupply
Certification: GMP; ISO; SGS
Model Number: Sarms Raw Powder

Payment & Shipping Terms:

Minimum Order Quantity: 10 G
Price: 295 USD / 10G
Packaging Details: vial and foil bag
Delivery Time: Within 24hours after received your payment
Payment Terms: Western Union, T/T, Money Gram, Paypal
Supply Ability: 1000kg/mouth
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Detailed Product Description
Product Name: GW-0742 Other Name: GW0742
Packaging: Foil Bag Or Vial Form: Powder
Assays: 99% Shipping: By Express (FedEx,UPS,DHL,EMS), By Air And By Sea
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SARMS Powder GW0742 / GW 0742 / GW610742 PPAR Agonist CAS 1196133-39-7

 

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Keywords: GW 0742, GW 0742 supplier, selective, potent, PPARδ, PPARdelta, agonists, Peroxisome, Proliferator-activating, Receptors, GW0742, GlaxoSmithKline, GSK, 2229, Tocris Bioscience
 
GW 0742​ Description:

 
Synonyms
  • GW 610742

The transcription factor peroxisome proliferator-activated receptor δ (PPARδ) is a member of the superfamily of nuclear hormone receptors and is implicated both in lipid metabolism and in the regulation of genes with potential roles in neurotoxicity. GW 0742 is a selective PPARδ agonist (EC50 = 1.1 nM) that exhibits 1,000-fold selectivity over the other human PPAR subtypes.1 GW 0742 exhibits time-dependent neuroprotection in low KCl-induced apoptosis in cerebellar granule neuronal cultures. Despite the neuroprotective properties observed, prolonged (48h) incubation with GW 0742 produced significant inherent toxicity. This cell death was determined to be apoptotic as identified with the TUNEL assay.2

 

SARMS Powder GW0742 / GW 0742 / GW610742 PPAR Agonist  CAS 1196133-39-7

Properties

Biological Activity

Potent and highly selective PPARδ agonist. EC50 values are 0.001, 1.1 and 2 μM for transactivation of human PPARδ, -α, and -γreceptors respectively. Neuroprotective in rat cerebellar granule neuronal cultures after brief (12-hour) exposure but exhibits inherent toxicity after prolonged (48-hour) incubation. Increases rate of fatty acid oxidation and protects against ischemia/reperfusion injury in neonatal and adult cardiomyocytes.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries

GW 0742 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

 
Description:
 
GW0742 is a high affinity PPAR-β/δ agonist reduces lung inflammation induced by bleomycin instillation in mice.
A high throughput screening campaign was conducted to identify small molecules with the ability to inhibit the interaction between the vitamin D receptor (VDR) and steroid receptor coactivator

 

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, 
 
 

Technical Data

M. Wt471.49
FormulaC21H17F4NO3S2
StorageDesiccate at +4°C
Purity≥98% (HPLC)
CAS Number317318-84-6

 
SARMS Powder GW0742 / GW 0742 / GW610742 PPAR Agonist  CAS 1196133-39-7
 
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We're specialized in pharma.raw materials ( hormone steroid powders, Steroids injectable liquids,peptides,Sarms), our company integrates R&D, producing, operating and marketing into an organic whole. We have authority of export and import, and have experience of export for 15 years.

Major Market: United States, United Kingdom, Australia, Canada, Sweden, Russia, Poland, Brazil, Israel, Netherlands, Germany,Spain, Switzerland, Poland and so on.
 
MOQ:100ml
Package:Disguised & Discreet pkg
Payment:T/T,Western Union,Moneygram,bitcoin
Delivery: sent out the goods within 24hours after receiving payment.
Custom Pass rate:99%
Resend policy is available if the parcle is seized or any quality problems been found.

After-sale Service :
Discounts are available for our second-time customers. We can provide recipes and professional suggestions to promote yourselves. Tracking number and packing photos can be given quickly after your goods sent. We are always here waiting for you!
 
 
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SARMS Powder GW0742 / GW 0742 / GW610742 PPAR Agonist  CAS 1196133-39-7

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