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|Purity:||99%||Appearance:||Off-white Crystalline Powder|
|Origin:||China||Usage:||Novel Pancreatic Lipase Inhibitor,Lipid-Lowering, Anti-obesity,fat Burner, Weight Loss,Hypoglycemic And Fat Saturation,dietary Supplements And For Appetite Suppression.|
|Storage Temp:||Room Temp|
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Product Name: Cetilistat
Chemical Properties: Off-white Cryst
Usage: A novel pancreatic lipase inhibitor for the treatment of obesity in both diabetic and non-diabetic patients.
|Synonyms:||4H-3,1-Benzoxazin-4-one,2-(hexadecyloxy)-6-Methyl-;Xinli orlistat;cetilistat;Cetilistat(Alt-962);Cetilstat;Cetilistat (282526-98-1);2-(Hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one;2-(Hexadecycloxy)-6-methyl-4H-3,1-benzoxazin-4-one|
|Product Categories:||Cetilistat;Other series;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;-;Pharmaceuticals;API|
|Chemical Properties||Off-white Cryst|
|Uses||A novel pancreatic lipase inhibitor for the treatment of obesity in both diabetic and non-diabetic patients.|
Cetilistat is a drug designed to treat obesity. It acts in the same way as the older drug orlistat (Xenical) by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested
In human trials, cetilistat was shown to produce similar weight loss to orlistat, but also produced similar side effects such as oily, loose stools, fecal incontinence, frequent bowel movements, and flatulence.It is likely that the same precautions would apply in that absorption of fat-soluble vitamins and other fat-soluble nutrients may be inhibited, requiring vitamin supplements to be used to avoid deficiencies.
Cetilistat has completed Phase 1 and 2 trials in the West and is currently in Phase 3 trials in Japan where it is partnered with Takeda. Norgina BV has now acquired the full global rights to cetilistat from Alizyme after the latter went into administration.
A published phase 2 trial found cetilistat significantly reduced weight with and was better tolerated than orlistat.
Obesity predisposes to serious illness
Obesity is now the most common nutritional disorder in western industrialised countries. Defined as a body mass index of greater than 30, it arises from the accumulation of excess fat in the body from over consumption of fatty foods.
Prevalence of obesity in the US and Europe has reached epidemic levels. Data from the WHO’s MONICA (Multinational MONItoring of trends and determinants in CArdiovascular disease) project show that in some parts of Europe over 70% of men aged 55 to 64 are clinically obese or overweight (BMI >25) as well as almost 70% of women in this age group. One in five of all Americans is obese and one in three overweight. Furthermore, increasing rates of childhood obesity are likely to exacerbate the trend towards increasing obesity in adulthood.
There is a strong association between obesity and increased risk of cardiovascular disease and diabetes and possibly certain cancers, such as breast and colorectal cancer. The dramatic rise in the incidence of type 2 diabetes is largely due to the increased prevalence of obesity. Increases in body weight lead to changes in blood lipid and cholesterol levels, predisposing to increased risk of atherosclerosis.
Therapeutic approaches to treatment of obesity
The growing prevalence of obesity has stimulated the search for drugs to treat this condition. Various therapeutic strategies have been explored, including:
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