MOQ 25KG(1drum) Phenacetin USA Phenacetin Canada
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Phenacetin was considered by previous IARC Working Groups in 1976 and 1980 (IARC, 1977, 1980). Analgesic mixtures containing phenacetin were considered by a previous IARC Working Group in 1987 (IARC, 1987a). Since that time, new data have become available, these have been incorporated into the Monograph, and taken into consideration in the present evaluation.
Phenacetin was used as an analgesic and fever-reducing drug in both human and veterinary medicine for many years. It was introduced into therapy in 1887 and was extensively used in analgesic mixtures until it was implicated in kidney disease (nephropathy) due to abuse of analgesics. Phenacetin also was once used as a stabilizer for hydrogen peroxide in hair-bleaching preparations .
Analgesic mixtures containing phenacetin were previously marketed as tablets or capsules containing between 150 and 300 mg phenacetin. Common combinations were: 150 mg phenacetin, 230 mg aspirin, and 15 or 30 mg caffeine; or 150 mg phenacetin, 230 mg aspirin, 30 mg caffeine, and 8, 15, 30, or 60 mg codeine phosphate. Phenacetin alone was also available in 250 and 300 mg doses as tablets, and up to 500 mg doses as powder. The usual dose was 300 mg 4–6 times per day, and the daily dose was not to exceed 2 g .
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