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Steroid Raw Powder 7-Ketodehydroepiandrosterone (7-keto-DHEA) For Bodybuilding Cas. 566-19-8
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7-Ketodehydroepiandrosterone (7-keto-DHEA), also known as 7-oxoprasterone, is a steroid produced by metabolism of the prohormone dehydroepiandrosterone (DHEA). 7-Keto-DHEA is not directly converted to testosterone or estrogen, and has thus been investigated as a potentially more useful relative of DHEA.It is often used as the acetate ester prodrug 7-keto-DHEA acetate.
While in vitro and animal studies have suggested potential uses for 7-keto-DHEA in humans, there is currently limited scientific evidence to support its use as a weight-loss aid, muscle-builder, immune stimulant, or for any other clinical use.One randomized, placebo-controlled research study on dieting and exercising healthy overweight individuals found 7-keto-DHEA significantly increased body-weight loss and fat-loss.7-Keto-DHEA is marketed as a dietary supplement with the implication that it may accelerate weight loss, increase metabolism, enhance memory, or prevent age-related changes. When used in a topical (skin lotion) product 7-keto-DHEA caused long-lasting changes in the body's levels of testosterone, epitestosterone, estradiol, and other steroid hormones. Researchers have raised concern that supplements may trigger positive tests for performance-enhancing drugs.
Synonyms: Androst-5-ene-7,17-dione,3b-hydroxy- (8CI);3b-Hydroxy-5-androstene-7,17-dione;5-Androsten-3b-ol-7,17-dione;7-Keto-DHEA;7-Oxo-DHEA;Androst-5-ene-7,17-dione,3-hydroxy-, (3b)-;
M F: C19H26O3
M W: 304.43
Density: 1.19 g/cm3
Boiling Point: 477.1 oC at 760 mmHg
Melting Point: 240.0~244.0 oC
Flash Point: 256.5 oC
Refractive index: 1.569
Appearance: White powder
Quality Standard: Enterprise Standard
Usage: It is the intermediate of synthesizing male hormone and female hormone. It is often used as the acetate ester prodrug 7-Keto-DHEA acetate. 7-Keto is marketed as a dietary supplement with the implication that it may accelerate weight loss, increase metabolism, enhance memory, or prevent age-related changes. When used in a topical (skin lotion) product 7-Keto caused long-lasting changes in the body's levels of testosterone, estradiol, and other steroid hormones
7-Keto-DHEA (also known as 7-Keto, 7-ketodehydroepiandrosterone, or 7-oxodehydroepiandrosterone) is a steroid produced by metabolism of the prohormone dehydroepiandrosterone. It is often used as the acetate ester prodrug 7-Keto-DHEA acetate.
7-Keto is unique among other derivatives of DHEA because of its oxygenated 7-position. This molecular configuration imparts different characteristics to the molecule, and research reveals that 7-Keto DHEA has multiple distinct effects in the body. Such as, Increased metabolism/weight loss, Age-related immune enhancement
Effects and uses
7-Keto-DHEA is unique among other derivatives of DHEA because of its oxygenated 7-position. This molecular configuration imparts different characteristics to the molecule, and research reveals that 7-keto-DHEA has multiple distinct effects in the body.
Increased metabolism/weight loss
7-Keto-DHEA demonstrates documented thermogenic activity in rats. This is accomplished through the activation of three thermogenic enzymes: Glycerol-3-Phosphate Dehydrogenase, Malic Enzyme and Fatty Acyl CoA Oxidase. In keeping with the biological definition of thermogenesis, all three of these enzyme activations drive energy-producing substrates in a direction of less efficient ATP production relative to heat production. The enzymes also promote the utilization of fat stores for energy and heat production. This is the basis for the ability of 7-keto-DHEA to enhance thermogenesis and, through that mechanism, accelerate the utilization of fat stores for energy.
A 2007 study demonstrated that administration of 7-keto-DHEA to overweight adults in conjunction with a calorie-restricted diet effectively reverses the decline in resting metabolic rate (RMR) normally associated with dieting. 7-Keto-DHEA demonstrated an ability to increase RMR by 1.4% above baseline levels and demonstrated a 5.4% increase in daily RMR when administered with a calorie-restricted diet.
7-Keto-DHEA achieves this thermogenic effect without cardiovascular or central nervous system side effects, which are commonly seen with stimulant-associated thermogenic agents.
Age-related immune enhancement
Although the aging process affects all of the segments of the immune system, investigators have identified abnormalities in the cellular or T-cell mediated immune function in the elderly. The decline in T-cell immune function is associated with an increased susceptibility to infections.For example, individuals with age-related declines in cellular immunity have an impaired response to influenza vaccine, making them more susceptible to getting the “flu” even though they have had their flu shot.
In a clinical study presented at the Federation of American Societies for Experimental Biology meeting in April 2004, the effect of 7-keto-DHEA was evaluated in regard to its effect on elderly immune function.
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