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Bodybuilding Lyophilized Solid Peptide GDF-8 (Growth / Differentiation Factor 8 / Myostatin) For Muscle Building

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Bodybuilding Lyophilized Solid Peptide GDF-8 (Growth / Differentiation Factor 8 / Myostatin) For Muscle Building

China Bodybuilding Lyophilized Solid Peptide GDF-8 (Growth / Differentiation Factor 8 / Myostatin) For Muscle Building supplier

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Product Details:

Place of Origin: Hubei, China
Brand Name: saichuang
Certification: ISO9001, USP, BP, GMP
Model Number: Peptides

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Minimum Order Quantity: 10g
Price: Negotiate
Packaging Details: discreet package or as required
Delivery Time: 5~8 working days
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Supply Ability: 5000KG/week
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Detailed Product Description
Name: GDF-8 Appearance: Powder
Assay: 99% Min. MOQ: 10vials
Grade: Pharma Grade Package: Safety And Discreet Pkg
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Bodybuilding Lyophilized Solid Peptide GDF-8 (Growth / Differentiation Factor 8 / Myostatin) For Muscle Building
 
 
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GDF-8 (Growth/differentiation factor 8, myostatin)


GDF-8 (Growth/differentiation factor 8, myostatin) acts specifically as a negative regulator of skeletal muscle growth. GDF-8 is a secreted TGF beta protein family member that inhibits muscle differentiation and growth. GDF-8 binds to the activin type II receptor.

Format
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Alternate Names
GDF-8; Growth/differentiation factor 8; Myostatin; MSTN; GDF8

Antigen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GDF-8.

Storage
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

 

Description

 

Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.

 

Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in both copies of the myostatin gene have significantly more muscle mass and are stronger than normal. There is hope that studies into myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.

 

In humans


In 2004, a German boy was diagnosed with a mutation in both copies of the myostatin-producing gene, making him considerably stronger than his peers. His mother has a mutation in one copy of the gene.

An American boy born in 2005 was diagnosed with a clinically similar condition, but with a somewhat different cause:[27] his body produces a normal level of functional myostatin, but because he is stronger and more muscular than most others his age, a defect in his myostatin receptors is thought to prevent his muscle cells from responding normally to myostatin. He appeared on the television show World's Strongest Toddler.[citation needed] Google search

 

Therapeutic potential


Further research into myostatin and the myostatin gene may lead to therapies for muscular dystrophy.[9][28] The idea is to introduce substances that block myostatin. A monoclonal antibody specific to myostatin increases muscle mass in miceand monkeys.

A two-week treatment of normal mice with soluble activin type IIB receptor, a molecule that is normally attached to cells and binds to myostatin, leads to a significantly increased muscle mass (up to 60%). It is thought that binding of myostatin to the soluble activin receptor prevents it from interacting with the cell-bound receptors.[citation needed]

It remains unclear as to whether long-term treatment of muscular dystrophy with myostatin inhibitors is beneficial, as the depletion of muscle stem cells could worsen the disease later on. As of 2012, no myostatin-inhibiting drugs for humans are on the market. An antibody genetically engineered to neutralize myostatin, stamulumab, which was under development by pharmaceutical company Wyeth,[31] is no longer under development. Some athletes, eager to get their hands on such drugs, turn to the internet where fake "myostatin blockers" are being sold.

Myostatin levels are effectively decreased by creatine supplementation.

Myostatin levels can be temporarily reduced using a cholesterol-conjugated siRNA gene knockdown.

 

Athletic use


Inhibition of myostatin leads to muscle hyperplasia and hypertrophy. Myostatin inhibitors can improve athletic performance and therefore there is a concern these inhibitors might be abused in the field of sports. However, studies in mice suggest that myostatin inhibition does not directly increase the strength of individual muscle fibers.

 

Bodybuilding Lyophilized Solid Peptide GDF-8 (Growth / Differentiation Factor 8 / Myostatin) For Muscle Building

 

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Bodybuilding Lyophilized Solid Peptide GDF-8 (Growth / Differentiation Factor 8 / Myostatin) For Muscle Building
 

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