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|Product Name:||Procaine||Other Name:||2-(Diethylamino)ethyl 4-aminobenzoate|
|M.W.:||236.31||Packaging:||Foil Bag Or Vial|
|Appearance:||White Crystalline Powder||Assays:||99%|
|Shipping:||By Express (FedEx,UPS,DHL,EMS), By Air And By Sea||Payment:||Estern Union, Money Gram, T/T And Paypal|
Procaine may also be used for purposes other than those listed here.
Procaine is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions, procaine is referred to generically as novocaine. It acts mainly as a sodium channel blocker.Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion-enhancing, and mood-enhancing effects.
|Synonyms:||2-(Diethylamino)ethyl 4-aminobenzoate;2-(Diethylamino)ethyl p-aminobenzoate;2-(diethylamino)ethylp-aminobenzoate;2-diethylaminoethyl4-aminobenzoate;2-Diethylaminoethylester kyseliny p-aminobenzoove;2-diethylaminoethylesterkyselinyp-aminobenzoove;2-diethylaminoethylp-aminobenzoate;4-Aminobenzoic acid diethylaminoethyl ester|
|PROCAINE Chemical Properties|
|Boiling point||378.78°C (rough estimate)|
|density||1.0604 (rough estimate)|
|refractive index||1.5430 (estimate)|
|PROCAINE Usage And Synthesis|
|Uses||inhibitor of sodium channel|
|Definition||ChEBI: A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.|
|Contact allergens||Procaine is a local anesthetic with para-amino function. Sensitization mainly concerns the medical, dental, and veterinary professions.|
Used as a local anesthetic primarily in oral surgery
Procaine is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery. Procaine (like cocaine) has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine. Procaine is an ester anesthetic. It is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-aminobenzoic acid (PABA), which is then excreted by the kidneys into the urine.
Mechanism of action
Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Procaine has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.
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|Lidocaine||Tetracaine hydrochloride||Bupivacaine hydrochloride|
|Linocaine hydrochloride||Pramoxine hydrochloride||Dibucaine hydrochloride|
|Procaine||Articaine hydrochloride||Ropivacaine hydrochloride|
|Procaine hydrochloride||Benzocaine hydrochloride||Levobupivacaine Hcl
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