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Cas 379270-37-8 Tenofovir Alafenamide TAF / GS-7340 Reverse Transcriptase inhibitor Raw Powder

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Cas 379270-37-8 Tenofovir Alafenamide TAF / GS-7340 Reverse Transcriptase inhibitor Raw Powder

China Cas 379270-37-8 Tenofovir Alafenamide TAF / GS-7340 Reverse Transcriptase inhibitor Raw Powder supplier

Large Image :  Cas 379270-37-8 Tenofovir Alafenamide TAF / GS-7340 Reverse Transcriptase inhibitor Raw Powder

Product Details:

Place of Origin: China
Brand Name: Pharmasupply
Certification: GMP; ISO; SGS
Model Number: Pharma Raw Powder

Payment & Shipping Terms:

Minimum Order Quantity: 10 G
Price: 295 USD / 10G
Packaging Details: vial and foil bag
Delivery Time: Within 24hours after received your payment
Payment Terms: Western Union, T/T, Money Gram, Paypal
Supply Ability: 1000kg/mouth
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Detailed Product Description
Product Name: GS-7340 Other Name: Tenofovir Alafenamide
Packaging: Foil Bag Or Vial Form: Powder
Assays: 99% Shipping: By Express (FedEx,UPS,DHL,EMS), By Air And By Sea
Payment: Western Union, Money Gram, T/T And Paypal WhatsApp: +8618873306038
Email: Kathelin@yccreate.com

Cas 379270-37-8 Tenofovir Alafenamide ( TAF ) / GS-7340 Reverse Transcriptase inhibitor Raw Powder

 


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  • Email:kathelin@yccreate.com
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ABSTRACT

Tenofovir alafenamide (TAF) is a prodrug of tenofovir (TFV) currently in clinical evaluation for treatment for HIV and hepatitis B virus (HBV) infections. Since the target tissue for HBV is the liver, the hepatic delivery and metabolism of TAF in primary human hepatocytes in vitro and in dogs in vivo were evaluated here. Incubation of primary human hepatocytes with TAF resulted in high levels of the pharmacologically active metabolite tenofovir diphosphate (TFV-DP), which persisted in the cell with a half-life of >24 h. In addition to passive permeability, studies of transfected cell lines suggest that the hepatic uptake of TAF is also facilitated by the organic anion-transporting polypeptides 1B1 and 1B3 (OATP1B1 and OATP1B3, respectively). In order to inhibit HBV reverse transcriptase, TAF must be converted to the pharmacologically active form, TFV-DP. While cathepsin A is known to be the major enzyme hydrolyzing TAF in cells targeted by HIV, including lymphocytes and macrophages, TAF was primarily hydrolyzed by carboxylesterase 1 (CES1) in primary human hepatocytes, with cathepsin A making a small contribution. Following oral administration of TAF to dogs for 7 days, TAF was rapidly absorbed. The appearance of the major metabolite TFV in plasma was accompanied by a rapid decline in circulating TAF. Consistent with the in vitro data, high and persistent levels of TFV-DP were observed in dog livers. Notably, higher liver TFV-DP levels were observed after administration of TAF than those given TDF. These results support the clinical testing of once-daily low-dose TAF for the treatment of HBV infection.
 

Chemical Information

  
ActionsInhibitor
M. Wt476.47
FormulaC21H29N6O5P
SolubilityDMSO
Purity>98%
Storageat -20°C 3 years Powder
CAS No.379270-37-8
SynonymsGS7340, GS 7340, Tenofovir alafenamide
SMILES codeCC(C)OC(=O)C(C)NP(=O)(COC(C)CN1C=NC2=C1N=CN=C2N)OC3=CC=CC=C3
Chemical Name(S)-isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate

 
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Cas 379270-37-8 Tenofovir Alafenamide TAF / GS-7340 Reverse Transcriptase inhibitor Raw Powder
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ABOUT US
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We're specialized in pharma.raw materials ( hormone steroid powders, Steroids injectable liquids,peptides,Sarms), our company integrates R&D, producing, operating and marketing into an organic whole. We have authority of export and import, and have experience of export for 15 years.

Major Market: United States, United Kingdom, Australia, Canada, Sweden, Russia, Poland, Brazil, Israel, Netherlands, Germany,Spain, Switzerland, Poland and so on.
 
MOQ:100g
Package:Disguised & Discreet pkg
Payment:T/T,Western Union,Moneygram,bitcoin
Delivery: sent out the goods within 24hours after receiving payment.
Custom Pass rate:99%
Resend policy is available if the parcle is seized or any quality problems been found.

After-sale Service :
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Cas 379270-37-8 Tenofovir Alafenamide TAF / GS-7340 Reverse Transcriptase inhibitor Raw Powder
 

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