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Buy 99% Phenacetin / Acetophenetidin / Fenacetina Manufacturer Local Anesthesia Powder
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|Phenacetin Basic information|
|Product Categories:||Amines;Aromatics;Other APIs;Intermediates & Fine Chemicals;Pharmaceuticals;Others;Organics|
|Phenacetin Chemical Properties|
|Melting point||133-136 °C(lit.)|
|Boiling point||132 °C / 4mmHg|
|density||1.1248 (rough estimate)|
|pka||pKa 2.2(H2O) (Uncertain);3.5(aqueous acetone) (Uncertain)|
|Water Solubility||0.076 g/100 mL|
|Stability:||Stable. Incompatible with strong oxidizing agents, strong acids.|
|CAS DataBase Reference||62-44-2(CAS DataBase Reference)|
|NIST Chemistry Reference||Acetamide, N-(4-ethoxyphenyl)-(62-44-2)|
|EPA Substance Registry System||Acetamide, N-(4-ethoxyphenyl)-(62-44-2)|
|RIDADR||UN 3077 9 / PGIII|
Phenacetin is a pain-relieving and fever-reducing drug, widely used from its introduction in 1887 until banned in the US by the FDA in 1983. Its use has declined because of its adverse effects, which include increased risk of certain cancers and kidney damage.
It is metabolized into paracetamol, which replaced it in some over-the-counter medications following the ban on phenacetin.
Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C." or aspirin-phenacetin-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia. However the U.S.
Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)
1.Phenacetin may be used as a treatment for rheumatoid arthritis.
2.Phenacetin used in veterinary medicine was shown to cause tumors in rats during experimental laboratory studies.
3.Acetaminophen is commonly used to treat arthritis.
4.phenacetin was commonly used as a fever reducer.
Usage 1 Analgesic, antipyretic. Component of APC tablets, analgesic mixture also containing aspirin and caffeine. Phenacetin is reasonably anticipated to be a human carcinogen; analgesic mixtures containing Phenacetin are listed as known human carcinogens.
Usage 2 glycosylation inhibitor
Usage 3 Used for organic synthesis of raw materials and drug intermediates from acetaminophen ether.
Usage 4 Antipyretic analgesics for the treatment of fever, headache, neuralgia.
Usage 5 Active pharmaceutical ingredient for Scientific Research.
The antipyretic effect is stronger than the analgesic effect. The effect of intensity is slow and long lasting, as aspirin, with low toxicity. research shows:
This product and its metabolites have antipyretic effects on acetaminophen. Because enzyme inhibitors do not convert phenylacetic acetate into paracetamol, there is still a significant antipyretic effect, so the antipyretic effect of the post-production line does not translate into paracetamol.
Mild phenacetin acetate analgesia usually lasts 3 to 4 hours; and synergistic, co-administration can improve the analgesic effect.
The main clinical application of antipyretic analgesics for small animals. This product is also a component of the APC Tablet PC.
Phenacetins should be Store in Cool and Dry Place.
How to dissolve Phenacetin ?
Phenacetin is a synthetic, white crystalline solid that is slightly soluble in water and benzene, soluble in acetone and very soluble in pyrimidine.
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag),or as required.
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
|Phenacetin Usage And Synthesis|
|Indications and Usage||Phenacetin is mainly used as an antipyretic analgesic, with slow and lasting effects, treating headaches, neuralgia, joint pain, and fever, and weakly resisting rheumatism and inflammation. Because of toxic side effects and the rapid development of similar drugs, however, it is no longer used alone, only as a raw material in combination with other drugs. Commonly combined with aspirin and caffeine to form a less toxic compound aspirin used to treat the common cold. Can make chlorpheniramine cold tablets by adding a small amount of chlorpheniramine to the above compound, used to treat colds with headache, neuralgia, rheumatism, etc. Can be used as a material for organic synthesis or a pharmaceutical intermediate.|
|Mechanisms of Action||On its own, phenacetin has no antipyretic or analgesic effects. In vivo, acetaminophen and paracetamol are metabolized and decomposed to create the antipyretic and analgesic effects. Its decomposites with ammonia and phenyl either not only have no antipyretic and analgesic effects, but also are major factors in its side effects.|
|Side Effects||Long term use may cause renal papillary necrosis and interstitial nephritis, and even induce renal pelvic cancer and bladder cancer. Phenacetin also makes the hemoglobin to form methemoglobin, decreasing blood oxygen carrying capacity, causing cyanosis. In addition, Phenacetin can cause hemolysis and hemolytic anemia, and is toxic to the retina. Long term use may cause also lead to dependence. Countries including America, Britain, German, and Japan have banned Phenacetin, or required packaging to note that it is “not indicated for long-term usage or large doses.”|
|Chemical Properties||Acetophenetidin is a fine, white, crystalline powder or solid. Odorless with a slightly bitter taste|
|Uses||Analgesic, antipyretic. Component of APC tablets, analgesic mixture also containing aspirin and caffeine. Phenacetin is reasonably anticipated to be a human carcinogen; analgesic mixtures containing Phenacetin are listed as known human carcinogens.|
|Definition||ChEBI: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a 4-ethoxyphenyl group.|
|Brand name||[Names previously used: Acetophenetidin; Acetphenetidin.].|
|General Description||Odorless fine white crystalline solid with a lightly bitter taste. Used as an analgesic medicine.|
|Air & Water Reactions||Insoluble in water.|
|Reactivity Profile||Phenacetin react with oxidizing agents, iodine and nitrating agents.|
|Fire Hazard||Flash point data for Phenacetin are not available but Phenacetin is probably combustible.|
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